2004 - 2009

1: Lesner A, Shilpi R, Ivanova A, Gawinowicz MA, Lesniak J, Nikolov D, Simm M. Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity. Biochem Biophys Res Commun. 2009 Nov 13;389(2):284-9.

2: Reich M, Lesner A, Legowska A, Sieńczyk M, Oleksyszyn J, Boehm BO, Burster T.Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells. Mol Immunol. 2009 Sep;46(15):2994-9.

3: Łegowska A, Debowski D, Lesner A, Wysocka M, Rolka K. Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors. Bioorg Med Chem. 2009 May 1;17(9):3302-7.

4: Lesner A, Wysocka M, Solek M, Legowska A, Rolka K. Low-molecular-weight aldehyde inhibitors of cathepsin G. Protein Pept Lett. 2009;16(4):408-10.

5: Sieńczyk M, Lesner A, Wysocka M, Legowska A, Pietrusewicz E, Rolka K, Oleksyszyn J. New potent cathepsin G phosphonate inhibitors. Bioorg Med Chem. 2008 Oct 1;16(19):8863-7.

6: Spichalska B, Lesner A, Wysocka M, Sledź M, Legowska A, Jaśkiewicz A, Miecznikowska H, Rolka K. The influence of substrate peptide length on human beta-tryptase specificity. J Pept Sci. 2008 Aug;14(8):917-23.

7: Wysocka M, Lesner A, Guzow K, Mackiewicz L, Legowska A, Wiczk W, Rolka K. Design of selective substrates of proteinase 3 using combinatorial chemistry methods. Anal Biochem. 2008 Jul 15;378(2):208-15.

8: Łegowska A, Bulak E, Wysocka M, Jaśkiewicz A, Lesner A, Debowski D, Rolka K. Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds. Bioorg Med Chem. 2008 May 15;16(10):5644-52.

9: Lesner A, Wysocka M, Guzow K, Wiczk W, Legowska A, Rolka K. Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods. Anal Biochem. 2008 Apr 15;375(2):306-12.

10: Wysocka M, Lesner A, Legowska A, Jaśkiewicz A, Miecznikowska H, Rolka K. Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1). Protein Pept Lett. 2008;15(3):260-4.

11: Li G, Aaron S, Kazmierczak K, Lesner A, Li Y, Ivanova A, Bentsman G, Potash MJ, Simm M. Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells. Immunol Cell Biol. 2007 Nov-Dec;85(8):603-9.

12: Zabłotna E, Jaśkiewicz A, Łegowska A, Miecznikowska H, Lesner A, Rolka K. Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure. J Pept Sci. 2007 Nov;13(11):749-55.

13: Kowalska J, Pszczoła K, Wilimowska-Pelc A, Lorenc-Kubis I, Zuziak E, Ługowski M, Łegowska A, Kwiatkowska A, Sleszyńska M, Lesner A, Walewska A, Zabłotna E, Rolka K, Wilusz T. Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis. Phytochemistry. 2007 Jun;68(11):1487-96.

14: Wysocka M, Legowska A, Bulak E, Jaśkiewicz A, Miecznikowska H, Lesner A, Rolka K. New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods. Mol Divers. 2007 May;11(2):93-9.

15: Wysocka M, Kwiatkowska B, Rzadkiewicz M, Lesner A, Rolka K. Selection of new  chromogenic substrates of serine proteinases using combinatorial chemistry methods. Comb Chem High Throughput Screen. 2007 Mar;10(3):171-80.

16: Lesner A, Li Y, Nitkiewicz J, Li G, Kartvelishvili A, Kartvelishvili M, Simm M. A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer. J Immunol. 2005 Aug 15;175(4):2548-54.

17: Lesner A, Kartvelishvili A, Lesniak J, Nikolov D, Kartvelishvili M, Trillo-Pazos G, Zablotna E, Simm M. Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1. Biochemistry. 2004 Dec 28;43(51):16203-11.

18: Zabłotna E, Dysasz H, Lesner A, Jaśkiewicz A, Kaźmierczak K, Miecznikowska H, Rolka K. A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach. Biochem Biophys Res Commun. 2004 Jun 18;319(1):185-8.

19: Kartvelishvili A, Lesner A, Szponar M, Simm M. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. Immunol Lett. 2004 Apr 30;93(1):79-86.