Publikacje

Publikacje członków Pracowni Sensybilizatorów Biologicznych

Zachęcamy do lektury!

2022
  1. Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Witold Kozak, Janusz Rak,
    Konrad Kubiński, Maciej Masłyk, Aleksandra Martyna, Magdalena Śliwka-Kaszyńska, Joanna Wietrzyk,
    Marta Świtalska, Alessio Nocentini, Claudiu T. Supuran, Sebastian Demkowicz
    Development of Sulfamoylated 4‑(1-Phenyl‑1H‑1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer
    J. Med. Chem. 2022, 65, 5044−5056
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02220
  2. S. Makurat, Z. Cournia, J. Rak
    Inactive-to-active transition of human thymidine kinase 1 revealed by molecular dynamics simulations
    J. Chem. Inf. Model., 2022, 62(1), 142-149
    https://doi.org/10.1021/acs.jcim.1c01157
  3. M. Zdrowowicz, L. Chomicz-Mańka, K. Butowska, P. Spisz, K. Falkiewicz, A. Czaja, J. Rak
    DNA damage radiosensitizers geared towards hydrated electrons
    rozdział w: Practical aspects of computational chemistry, 5, edytorzy: J. Leszczynski, M. Shukla, Springer, 2022
    https://link.springer.com/book/10.1007%2F978-3-030-83244-5
2021
  1. E. Arthur-Baidoo, K. Falkiewicz, L. Chomicz-Mańka, A. Czaja, S. Demkowicz, K. Biernacki, W. Kozak, J. Rak, S. Denifl
    Electron-Induced Decomposition of Uracil-5-yl O-(N,N-dimethylsulfamate): Role of Methylation in Molecular Stability
    Int. J. Mol. Sci., 2021, 22(5), 2344
    https://www.mdpi.com/1422-0067/22/5/2344
  2. R. Szabla, M. Zdrowowicz, P. Spisz, N.J. Green, P. Stadlbauer, H. Kruse, J. Šponer, J. Rak
    2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
    Nature Communications, 2021, 12, 3018
    https://www.nature.com/articles/s41467-021-23300-y
  3. P. Storoniak, J. Rak, H. Wang, Y.J. Ko, K.H. Bowen
    Electrophilic properties of 2'-deoxyadenosine...thymine dimer: photoelectron spectroscopy and DFT studies
    J. Phys. Chem. A, 2021, 125(30), 6591-6599
    https://pubs.acs.org/doi/10.1021/acs.jpca.1c03803
  4. Q. Yuan, L. Chomicz-Mańka, S. Makurat, W. Cao, J. Rak, X. Wang
    Photoelectron spectroscopy and theoretical investigations of gaseous doubly deprotonated 2'-deoxynucleoside 5'-monophosphate dianions
    J. Phys. Chem. Lett., 2021, 12(39), 9463-9469
    https://pubs.acs.org/doi/10.1021/acs.jpclett.1c02678
2020
  1. P. Spisz, M. Zdrowowicz, W. Kozak, L. Chomicz-Mańka, K. Falkiewicz, S. Makurat, A. Sikorski, D. Wyrzykowski, J. Rak, E. Arthur-Baidoo, P. Ziegler, M. Salomao Rodrigues Costa, S. Denifl
    Uracil-5-yl O-Sulfamate: An Illusive Radiosensitizer. Pitfalls in Modeling the Radiosensitizing Derivatives of Nucleobases
    J. Phys. Chem. B, 2020, 124(27), 5600–5613
    https://pubs.acs.org/doi/10.1021/acs.jpcb.0c03844
  2. P. Spisz, W. Kozak, L. Chomicz-Mańka, S. Makurat, K. Falkiewicz, A. Sikorski, A. Czaja, J. Rak, M. Zdrowowicz
    5-(N-Trifluoromethylcarboxy)aminouracil as a Potential DNA Radiosensitizer and Its Radiochemical Conversion into N-Uracil-5-yloxamic Acid
    Int. J. Mol. Sci., 2020, 21(17), 6352
    https://www.mdpi.com/1422-0067/21/17/6352
  3. M. Paszkiewicz-Gawron, S. Makurat, J. Rak, M. Zdrowowicz, W. Lisowski, A. Zaleska-Medynska, E. Kowalska, P. Mazierski, J. Łuczak
    Theoretical and Experimental Studies on the Visible Light Activity of TiO2 Modified with Halide-Based Ionic Liquids
    Catalysts, 2020, 10(4), 371
    https://www.mdpi.com/2073-4344/10/4/371
  4. H. Myszka, D. Grzywacz, M. Zdrowowicz, P. Spisz, K. Butowska, J. Rak, J. Piosik, M. Jaśkiewicz, W. Kamysz, B. Liberek
    Design, synthesis and biological evaluation of betulin-3-yl 2-amino-2-deoxy-β-D-glycopyranosides
    Bioorganic Chemistry, 2020, 96, 103568
    https://www.sciencedirect.com/science/article/pii/S0045206819314208?via%3Dihub
  5. K. Butowska, K. Żamojć, M. Kogut, W. Kozak, D. Wyrzykowski, W. Wilczk, J. Czub, J. Piosik, J. Rak
    The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide-Doxorubicin Binding to DNA
    Int. J. Mol. Sci., 2020, 21(18), 6923
    https://www.mdpi.com/1422-0067/21/18/6923
  6. W. Kozak, S. Demkowicz, M. Daśko, J. Rachoń, J. Rak
    Modifications at the C-5 position of pyrimidine nucleosides
    Russ. Chem. Rev., 2020, 89(3), 281-310
    https://iopscience.iop.org/article/10.1070/RCR4919
2019
  1. R. Meißner, S. Makurat, W. Kozak, P. Limão-Vieira, J. Rak, S. Denifl 
    Electron-Induced Dissociation of the Potential Radiosensitizer 5-Selenocyanato-2′-deoxyuridine
    J. Phys. Chem. B, 2019, 123(6), 1274–1282
    https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.8b11523
  2. L. Cupellini, P. Wityk, B. Mennucci, J. Rak
    Photoinduced electron transfer in 5-bromouracil labeled DNA. A contrathermodynamic mechanism revisited by electron transfer theories
    Phys. Chem. Chem. Phys., 2019, 21, 4387-4393
    https://pubs.rsc.org/en/content/articlehtml/2019/cp/c8cp07700b
  3. S. Makurat, P. Spisz, W. Kozak, J. Rak, M. Zdrowowicz
    5-Iodo-4-thio-2′-Deoxyuridine as a Sensitizer of X-ray Induced Cancer Cell Killing
    Int. J. Mol. Sci. 2019, 20(6), 1308
    https://doi.org/10.3390/ijms20061308  
  4. P. Spisz, M. Zdrowowicz, S. Makurat, W. Kozak, K. Skotnicki, K. Bobrowski, J. Rak
    Why Does the Type of Halogen Atom Matter for the Radiosensitizing Properties of 5-Halogen Substituted 4-Thio-2′-Deoxyuridines?
    Molecules 2019, 24(15), 2819
    https://www.mdpi.com/1420-3049/24/15/2819  
  5. K. Butowska, W. Kozak, M. Zdrowowicz, S. Makurat, M. Rychłowski, A. Hać, A. Herman-Antosiewicz, J. Piosik, J. Rak
    Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies
    Structural Chemistry, 2019, 30, 2327-2338
    https://link.springer.com/article/10.1007/s11224-019-01428-4

     

2018
  1. J. Ameixa, E. Arthur–Baidoo, R. Meißner, S. Makurat, W. Kozak, K. Butowska, F. Ferreira da Silva, J. Rak, S. Denifl
    Low–energy electron–induced decomposition of 5–trifluoromethanesulfonyl–uracil: a potential radiosensitizer
    J. Chem. Phys., 2018, 149(16), 164307
    https://aip.scitation.org/doi/10.1063/1.5050594 
  2. Samanta Makurat, Magdalena Zdrowowicz, Lidia Chomicz-Mańka, Witold Kozak, Illia E. Serdiuk, Paweł Wityk, Alicja Kawecka, Marta Sosnowska, Janusz Rak
    5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2′-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity
    RSC Adv, 2018, 8(38), 21378-21388
    http://dx.doi.org/10.1039/C8RA03172J 
  3. Karolina Jagiełło, Samanta Makurat, Sylwester Pereć, Janusz Rak, Tomasz Puzyn 
    Molecular features of thymidine analogues governing the activity of human thymidine kinase
    Struct. Chem., 2018, 29(5), 1367-1374
    http://dx.doi.org/10.1007/s11224-018-1124-2
2017
  1. Kinga Westphal, Magdalena Zdrowowicz, Agnieszka Żylicz-Stachula, Janusz Rak
    Chemically–enzymatic synthesis of photosensitive DNA
    J. Photochem. Photobiol. B 2017, 167, 228–235
    http://dx.doi.org/10.1016/j.jphotobiol.2017.01.005     
  2. Paweł Wityk, Magdalena Zdrowowicz, Justyna Wiczk, Janusz Rak 
    UV-induced electron transfer between triethylamine and 5-bromo-2-deoxyuridine. A puzzle concerning the photochemical debromination of labeled DNA 
    J. Pharm.     Biomed. Anal. 2017, 142, 262–269 
    http://dx.doi.org/10.1016/j.jpba.2017.04.044
  3. Marta Sosnowska, Samanta Makurat, Magdalena Zdrowowicz, Janusz Rak 
    5‑Selenocyanatouracil: A Potential Hypoxic Radiosensitizer. Electron Attachment Induced Formation of Selenium Centered Radical 
    J. Phys. Chem. B 2017, 121, 6139−6147 
    http://dx.doi.org/10.1021/acs.jpcb.7b03633
  4. Justyna Czechowska, Alicja Kawecka, Anna Romanowska, Maria Marczak, Paweł Wityk, Karol Krzymiński, Beata Zadykowicz 
    Chemiluminogenic acridinium salts: A comparison study. Detection of intermediate entities appearing upon light generation 
    J. Lumin. 2017, 187, 102-112 
    http://dx.doi.org/10.1016/j.jlumin.2017.02.068 
  5. Justyna Łuczak, Marta Paszkiewicz-Gawron, Marta Długokęcka, Wojciech Lisowski, Ewelina Grabowska, Samanta Makurat, Janusz Rak, 
    Adriana Zaleska-Medynska 
    Visible light photocatalytic activity of ionic liquid-TiO2 spheres: effect of the ionic liquid's anion structure 
    ChemCatChem, Online: 6 Czer 2017 
    http://dx.doi.org/10.1002/cctc.201700861
  6. Krzysztof Żamojć, Magdalena Zdrowowicz, Paweł Błażej Rudnicki-Velasquez, Karol Krzymiński, 
    Bartłomiej Zaborowski, Paweł Niedziałkowski, Dagmara Jacewicz, Lech Chmurzyński
    The development of 1,3-diphenylisobenzofuran as a highly selective probe for the detection and quantitative determination of hydrogen peroxide 
    Free Radical Research, 2017, 51, 38-46
     
2016
  1. Magdalena Zdrowowicz, Paweł Wityk, Barbara Michalska, Janusz Rak
    5-Bromo-2′-deoxycytidine—a potential DNA photosensitizer
    Organic & Biomolecular Chemistry, 2016, 14, 9312-9321.
  2. Krzysztof Żamojć, Magdalena Zdrowowicz, Dagmara Jacewicz, Dariusz Wyrzykowski, Lech Chmurzyński
    Fluorescent and luminescent probes used for monitoring hydroxyl radical under biological conditions 
    Critical Reviews in Analytical Chemistry, 2016, 46, 160-169.
  3. Kinga Westphal, Konrad Skotnicki, Krzysztof Bobrowski, Janusz Rak
    Radiation damage to single stranded oligonucleotide trimers labelled with 5-iodopyrimidines
    Organic & Biomolecular Chemistry, 2016, 14, 9331-9337.
  4. Justyna Wiczk, Kinga Westphal, Janusz Rak
    Quantitative assay of photoinduced DNA strand breaks by real-time PCR
    Journal of Pharmaceutical and Biomedical Analysis, 2016, 128, 480–484.
  5. Piotr Storoniak, Janusz Rak, Yeaon Jae, Ko, Haopeng Wang, Kit H. Bowen
    Excess Electron Attachment to the Nucleoside Pair 2'-Deoxyadenosine (dA)-2'-Deoxythymidine (dT)
    The Journal of Physical Chemistry B, 2016, 120, 4955-4962.
  6. Michał Wera, Piotr Storoniak, Damian Trzybiński, Beata Zadykowicz
    Intramolecular interactions in multi-component crystals of acridinone/thioacridinone derivatives: Structural and energetics investigations
    Journal of Molecular Structure, 2016, 1125, 36-46.
  7. Damian Trzybiński, Beata Zadykowicz, Michał Wera, Illia E. Serdiuk, Andrzej Sieradzan, Artur Sikorski, Piotr Storoniak, Karol Krzymiński
    Structure, formation, thermodynamics and interactions in 9-carboxy-10-methylacridinium-based molecular systems
    New Journal of Chemistry, 2016, 40, 7359-7372.
  8. Samanta Makurat, Lidia Chomicz-Mańka, Janusz Rak
    Electrophilic 5-Substituted Uracils as Potential Radiosensitizers. A DFT Study.
    ChemPhysChem, 2016, 17(16), 2572-2578.
  9. Lidia Chomicz-Mańka, Paweł Wityk, Łukasz Golon, Magdalena Zdrowowicz, Justyna Wiczk, Kinga Westphal, Michał Żyndul, Samanta Makurat, Janusz Rak
    Consequences of Electron Attachment to Modified Nucleosides Incorporated into DNA
    rozdział w książce  “Handbook of Computational Chemistry”, Ed.: Jerzy Leszczynski, Springer Netherlands,
    DOI: 10.1007/978-94-007-6169-8_48-1.
  10. Michał Wera, Piotr Storoniak, Ilia E. Serdiuk, Beata Zadykowicz
    Structural considerations on acridine/acridinium derivatives : synthesis, crystal structure, Hirshfeld surface analysis and computational studies
    Journal of Molecular Structure, 2016, 1105, 41-53.
  11. Beata Zadykowicz, Michał Wera, Edward V. Sanin, Alexander I. Novikov, Alexander D. Roshal, Artur Sikorski, Piotr Storoniak, Jerzy Błażejowski
    Global and local interactions in the structure of crystalline 7-(diethylamino)-2-(2-oxo-2H-chromen-3-yl)chromenium perchlorate
    Structural Chemistry, 2016, 27(2), 637-649.
2015
  1. Kinga Westphal, Justyna Wiczk, Justyna Miloch, Gabriel Kciuk, Krzysztof Bobrowski, Janusz Rak
    Irreversible electron attachment - a key to DNA damage by solvated electrons in aqueous solution
    Organic & Biomolecular Chemistry, 2015, 13, 10362-10369.
  2. Janusz Rak, Lidia Chomicz, Justyna Wiczk, Kinga Westphal, Magdalena Zdrowowicz, Paweł Wityk, Michał Żyndul, Samanta Makurat, Łukasz Golon
    Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation
    The Journal of Physical Chemistry B, 2015, 119, 8227–8238.
  3. Magdalena Zdrowowicz, Lidia Chomicz, Michał Żyndul, Paweł Wityk, Janusz Rak, Tyler J. Wiegand,   Cameron G. Hanson, Amitava Adhikary, Michael D. Sevilla
    5-Thiocyanato-2′-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization
    Physical Chemistry Chemical Physics, 2015, 17, 16907-16916.
  4. Magdalena Zdrowowicz, Lidia Chomicz, Justyna Miloch, Justyna Wiczk, Janusz Rak, Gabriel Kciuk, Krzysztof Bobrowski
    Reactivity pattern of bromonucleosides induced by 2-hydroxypropyl radicals : photochemical, radiation chemical, and computational studies
    The Journal of Physical Chemistry B, 2015, 119, 6545-6554.
  5. Yajun Jian, Gengjie Lin, Lidia Chomicz, Lei Li
    Reactivity of Damaged Pyrimidines: Formation of a Schiff Base Intermediate at the Glycosidic Bond of Saturated Dihydrouridine
    Journal of American Chemical Society. 2015, 137, 3318−3329.
2014
  1. Lidia Chomicz, Alex Petrovici, Ian Archbold, Amitava Adhikary, Anil Kumar, Michael D. Sevilla, Janusz Rak
    An ESR and DFT study of hydration of the 20-deoxyuridine-5-yl radical : a possible hydroxyl radical intermediate.
    Chemical Communications. 2014, Vol. 50, iss. 93, s. 14605-14608.
  2. Lidia Chomicz, Łukasz Golon, Janusz Rak
    The radiosensitivity of 5- and 6-bromocytidine derivatives : electron induced DNA degradation.
    Physical Chemistry Chemical Physics. 2014, Vol. 16, no. 36, s. 19424-19428.
  3. Łukasz Golon, Lidia Chomicz, Janusz Rak
    Electron-induced single strand break in the nucleotide of 5- and 6-bromouridine : a DFT study.
    Chemical Physics Letters. 2014, Vol. 612, s. 289-294    .
  4. Agnieszka Żylicz-Stachula, Katarzyna Polska, Piotr Skowron, Janusz Rak
    Artificial plasmid labeled with 5-bromo-2'-deoxyuridine : a universal molecular system for strand break detection.
    ChemBioChem. 2014, Vol. 15, iss. 10, s. 1409-1412    .
  5. Magdalena Zdrowowicz, Barbara Michalska, Agnieszka Zylicz-Stachula, Janusz Rak
    Photoinduced Single Strand Breaks and Intrastrand Cross-Links in an Oligonucleotide Labeled with 5‑Bromouracil.
    Journal of Physical Chemistry. B. 2014, Vol. 118, s. 5009-5016.
  6. Piotr Storoniak, Haopeng Wang, Yeon Jae Ko, Xiang Li, Sarah T. Stokes, Soren Eustis, Kit H. Bowen, Janusz Rak
    Valence Anions of DNA-Related Systems in the Gas Phase: Computational and Anion Photoelectron Spectroscopy Studies.
    rozdział w książce Practical Aspects of Computational Chemistry III, 2014, s. 323-392.
  7. Justyna Wiczk, Justyna Miloch, Janusz Rak
    DHPLC and MS studies of a photoinduced intrastrand cross-link in DNA labeled with 5-bromo-2′-deoxyuridine.
    Journal of Photochemistry and Photobiology B: Biology, 2014, Vol. 130, s. 86-92.
  8. Lidia Chomicz, Al’ona Furmanchuk, Jerzy Leszczynski, Janusz Rak
    Electron induced single strand break and cyclization: A DFT study on the radiosensitization mechanism of the nucleotide of 8-bromoguanine.
    Physical Chemistry Chemical Physics, 2014, Vol. 16, iss. 14, s. 6568-6574. 
  9. Miłosz Wieczór, Paweł Wityk, Jacek Czub, Lidia Chomicz, Janusz Rak
    A first-principles study of electron attachment to the fully hydrated bromonucleobases.
    Chemical Physics Letters, 2014, Vol. 595-596, s. 133-137. 
  10. Dorota Zarzeczańska, Paweł Niedziałkowski, Anna Wcisło, Lidia Chomicz, Janusz Rak, Tadeusz Ossowski
    Synthesis, redox properties, and basicity of substituted 1-aminoanthraquinones: Spectroscopic, electrochemical, and computational studies in acetonitrile solutions.
    Structural Chemistry, 2014, Vol. 25, iss. 2, s. 625-634.
2013
  1. Lidia Chomicz, Jerzy Leszczyński, Janusz Rak.
    Electron-induced degradation of 8-bromo-2'-deoxyadenosine 3',5'-diphosphate, a DNA radiosensitizing nucleotide.
    Journal of Physical Chemistry. B. 2013, Vol. 117, iss. 29, s. 8681-8688.
  2. Lidia Chomicz, Magdalena Zdrowowicz, Franciszek Kasprzykowski, Janusz Rak, Angela Buonaugurio, Yi Wang, Kit H. Bowen.
    How to find out whether a 5-substituted uracil could be a potential DNA radiosensitizer.
    The Journal of Physical Chemistry Letters, 2013, Vol. 4, iss. 17, s. 2853-2857.
  3. Piotr Storoniak, Janusz Rak, Yeon Jae Ko, Haopeng Wang, Kit H. Bowen.
    Photoelectron spectroscopic and density functional theoretical studies of the 2'-deoxycytidine homodimer radical anion.
    The Journal of Chemical Physics, 2013, Vol. 139, iss. 7, art. no. 075101, s.1-9.
  4. Jeanette Kheir, Lidia Chomicz, Alyson Engle, Janusz Rak, Michael D. Sevilla.
    Presolvated low energy electron attachment to peptide methyl esters in aqueous solution: C-O bond cleavage at 77 K.
    Journal of Physical Chemistry. B, 2013, Vol. 117, iss. 10, s. 2872-2877.
  5. Justyna Wiczk, Justyna Miloch, Janusz Rak.
    UV-induced strand breaks in double-stranded DNA labeled with 5-bromouracil: frank or secondary?
    The Journal of Physical Chemistry Letters, 2013, Vol. 4, iss. 22, s. 4014-4018.
  6. Krzysztof Żamojć, Dagmara Jacewicz, Magdalena Zdrowowicz, Lech Chmurzyński.
    Kinetics of the reaction between 1,3-diphenylisobenzofuran and nitrogen dioxide studied by steady-state fluorescence.
    Research on Chemical Intermediates, 2013, Vol. 39 iss. 7, s. 3023-3031
2012
  1. Katarzyna Polska, Janusz Rak, Andrew Bass, Pierre Cloutier, Leon Sanche.
    Electron stimulated desorption of anions from native and brominated single stranded oligonucleotide trimers.
    The Journal of Chemical Physics. - 2012, Vol. 136, iss. 7, art. no. 075101.
  2. Lidia Chomicz, Janusz Rak, Piotr Storoniak.
    Electron-induced elimination of the bromide anion from brominated nucleobases. A computational study.
    Journal of Physical Chemistry. B. - 2012, Vol. 116, iss. 19, s. 5612-5619.
  3. Yeunsoo Park, Katarzyna Polska, Janusz Rak, J. Richard Wagner, Léon Sanche.
    Fundamental mechanisms of DNA radiosensitization: damage induced by low-energy electrons in brominated oligonucleotide trimers.
    Journal of Physical Chemistry. B. - 2012, Vol. 116, iss. 32, s. 9676-9682.
  4. Piotr Storoniak, Janusz Rak, Yeon Jae Ko, Haopeng Wang, Kit H. Bowen.
    Photoelectron spectroscopy and computational modeling of thymidine homodimer anions.
    Journal of Physical Chemistry. B. - 2012, Vol. 116, iss. 48, s. 13975-13981.
  5. Yeon Jae Ko, Piotr Storoniak, Haopeng Wang, Kit H. Bowen, Janusz Rak.
    Photoelectron spectroscopy and density functional theory studies on the uridine homodimer radical anions.
    The Journal of Chemical Physics. - 2012, Vol. 137, iss. 20, art. no. 205101.

 

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Data publikacji: piątek, 7. Marzec 2014 - 18:15; osoba wprowadzająca: Lidia Chomicz Ostatnia zmiana: środa, 30. Marzec 2022 - 12:37; osoba wprowadzająca: Lidia Chomicz