2010 - obecnie
2018
Gruba N, Rodriguez Martinez JI, Grzywa R, Wysocka M, Skoreński M, Dabrowska A, Łęcka M, Suder P, Sieńczyk M, Pyrć K, Lesner A. One step beyond: Design of substrates spanning primed positions of Zika virus NS2B-NS3 protease. ACS Med Chem Lett. 2018, 9, 1025-1029.
Hahn J, Schauer C, Czegley C, King L, Petru L, Schmid B, Weidner D, Reinwald C, Biermann MHC, Blaunder S, Ernst J, Lesner A, Bauerle T, Palmisano R, Christiansen S, Herrmann M, Bozec A, Gruber R, Schett G, Hoffmann MH. Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases. FASEB J. 2018 Aug. fj201800752R. doi: 10.1096/fj.201800752R.
Seren S, Rashed Abouzaid M, Eulenberg-Gustavus C, Hirschfeld J, Nasr Soliman H, Jerke U, N'Guessan K, Dallet-Choisy S, LesnerALauritze C, Schacher B,Eickholz P, Nag N, Szell M, Croix C Viud-Massurad MC, Al Farraj Aldosari A, Ragunatha S, Ibrahim Mostafa M, Giampieri F, Battino M, Cornillier H, Lorette G, Stephan JL, Goizet C, Pedersen J, Gauthier F, Jenne DE, Marchand-Adam S, Chapple IL, Kettritz R, Korkmaz B. Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. J Biol Chem. 2018 Aug. 293(32):12415-12428.
Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, Łęgowska M, Lesner A, Marchand-Adam S, McKaig SJ, Moss C, Peersen J, Roberts H, Scheiber A, Seren S, Thakker NS. Therapeutic targeting of cathepsn C: from pathophysiology to treatment. Pharmacol h. 2018 Oct.190:202-236.
Popow-Stellmaszyk J, Bajorowicz B, Malankowska A, Wysocka M, Klimczyuk T, Zaleska-Medynska A, Lesner A. Design, synthesis, and enzymatic evaluation of novel ZnO quantum dot-based assay for detection of proteinase 3 activity. Bioconjug Chem. 2018 Apr 20. doi: 10.1021/acs.bioconjchem.8b00100.
Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghildd J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J. A novel biological role of peptidyl-arginine deiminases: citrullination of cathelicidin LL-37 controls the immunostimulatory potential of cell-free DNA. J Immunol. 2018 Apr 1;200(7):2327-2340. doi: 10.4049/jimmunol.1701391.
Guarino C, Gruba N, Grzywa R, Dyguda-Kazimierowicz E, Hamon Y, Łęgowska M, Skorński M, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Jenne DE, Sieńczyk M, Lesner A, Gauthier F, Korkmaz B. Exploring the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis. J Med Chem. 2018 Mar 8;61(5):1858-1870. doi: 10.1021/acs.jmedchem.7b01416.
Zarzecka U, Modrak-Wojcik A, Bayassi M, Szewczyk M, Gieldon A, Lesner A, Koper T, Bzowska A, Sanguinetti M, Backert S, Lipinska B, Skorko-Glonek J. Biochemical properties of the HtRa homolog from bacterium Stenotrophomonas maltophilia. Int J Biol Macromol. 2018 Apr 1;109:992-1005. doi: 10.1016/j.ijbiomac.2017.11.086.
2017
Wysocka M, Sychowska K, Gruba N, Winiarski Ł, Skoreński M, Psurski M, Makowska J, Giełdoń A, Wenta T, Jarząb M, Glaza P, Zdancewicz J, Sieńczyk M, Lipińska B, Lesner A. Selection of effective HtrA3 activators using combinatorial chemistry. ACS Comb. Sci. 2017 Sep 11;19(9):565-573. doi: 10.1021/acscombsci.7b00051.
Wenta T, Glaza P, Jarząb M, Zarzecka U, Żurawa-Janicka D, Lesner A, Skórko-Glonek J, Lipińska B. The role of the LB structural loop and its interaction with the PDZ domain of the human Htra3 protease. Biochim Biophys Acta. 2017 Sep;1865(9):1141-1151. doi: 10.1016/j.bbapap.2017.06.013.
Guarino C, Hamon Y, Croix C, Lamort AS, Dallet-Choisy S, Marchand-Adam S, Lesner A, Baranek T, Viaud-Massuard MC, Lauritzen C, Pedersen J, Heuzé-Vourc'h N, Si-Tahar M, Fıratlı E, Jenne DE, Gauthier F, Horwitz MS, Borregaard N, Korkmaz B. Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases. Biochem Pharmacol. 2017 May 1;131:52-67. doi: 10.1016/j.bcp.2017.02.009.
2016
Strzelecka P, Czaplinska D, Sadej R, Wardowska A, Pikula M, Lesner A. Simplified, serine-rich theta-defensin analogues as antitumor peptides. Chem Biol Drug Des. 2016 Dec 22. doi: 10.1111/cbdd.12927.
Gruba N, Rodriguez Martinez JI, Grzywa R, Wysocka M, Skoreński M, Burmistrz M, Łęcka M, Lesner A, Sieńczyk M, Pyrć K. Substrate profiling of Zika virus NS2B-NS3 protease. FEBS Lett. 2016 Oct;590(20):3459-3468. doi: 10.1002/1873-3468.12443.
Łęgowska M, Hamon Y, Wojtysiak A, Grzywa R, Sieńczyk M, Burster T, Korkmaz B, Lesner A. Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples. Arch Biochem Biophys. 2016 Dec 15;612:91-102. doi: 10.1016/j.abb.2016.10.007.
Figaj D, Gieldon A, Bartczak M, Koper T, Zarzecka U, Lesner A, Lipinska B, Skorko-Glonek J. The LD loop as an important structural element required for transmission of the allosteric signal in the HtrA (DegP) protease from Escherichia coli. FEBS J. 2016 Sep;283(18):3471-87. doi: 10.1111/febs.13822.
Korkmaz B, Lesner A, Guarino C, Wysocka M, Kellenberger C, Watier H, Specks U, Gauthier F, Jenne DE. Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease. Pharmacol Rev. 2016 Jul;68(3):603-30. doi: 10.1124/pr.115.012104.
Gruba N, Wysocka M, Brzezińska M, Dębowski D, Sieńczyk M, Gorodkiewicz E, Guszcz T, Czaplewski C, Rolka K, Lesner A. Bladder cancer detection using a peptide substrate of the 20S proteasome. FEBS J. 2016 Aug;283(15):2929-48. doi: 10.1111/febs.13786.
Kosikowska P, Lesner A. Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015). Expert Opin Ther Pat. 2016 Jun;26(6):689-702. doi: 10.1080/13543776.2016.1176149.
Eipper S, Steiner R, Lesner A, Sienczyk M, Palesch D, Halatsch ME, Zaczynska E, Heim C, Hartmann MD, Zimecki M, Wirtz CR, Burster T. Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G. PLoS One. 2016 Mar 17;11(3):e0151509. doi: 10.1371/journal.pone.0151509.
Wysocka M, Gruba N, Grzywa R, Giełdoń A, Bąchor R, Brzozowski K, Sieńczyk M, Dieter J, Szewczuk Z, Rolka K, Lesner A. PEGylated substrates of NSP4 protease: A tool to study protease specificity. Sci Rep. 2016 Mar 9;6:22856. doi: 10.1038/srep22856.
2015
Hamon Y, Legowska M, Fergelot P, Dallet-Choisy S, Newell L, Vanderlynden L, Kord Valeshabad A, Acrich K, Kord H, Charalampos T, Morice-Picard F, Surplice I, Zoidakis J, David K, Vlahou A, Ragunatha S, Nagy N, Farkas K, Széll M, Goizet C, Schacher B, Battino M, Al Farraj Aldosari A, Wang X, Liu Y, Marchand-Adam S, Lesner A, Kara E, Korkmaz-Icöz S, Moss C, Eickholz P, Taieb A, Kavukcu S, Jenne DE, Gauthier F, Korkmaz B. Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome. FEBS J. 2015 Nov 26. doi: 10.1111/febs.13605.
Kosikowska P, Pikula M, Langa P, Trzonkowski P, Obuchowski M, Lesner A. Synthesis and evaluation of iological activity of antimicrobial – pro-proliferative peptide conjugates. PLoS One. 2015 Oct 16;10(10):e0140377.
Gruba N, Wysocka M, Brzezińska M, Debowski D, Rolka K, Martin N, Lesner A. Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome. Anal Biochem. 2015 Aug 24. pii: S0003-2697(15)00395-4.
Glaza P, Osipiuk J, Wenta T, Zurawa-Janicka D, Jarzab M, Lesner A, Banecki B, Skorko-Glonek J, Joachimiak A, Lipinska B. Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains. PLoS One. 2015 Jun 25;10(6):e0131142.
Koper T, Polit A, Sobiecka-Szkatula A, Wegrzyn K, Scire A, Figaj D, Kadzinski L, Zarzecka U, Zurawa-Janicka D, Banecki B, Lesner A, Tanfani F, Lipinska B, Skorko-Glonek J. Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli. PLoS One. 2015 Feb 24;10(2):e0117413.
Wysocka M, Wojtysiak A, Okońska M, Gruba N, Jarząb M, Wenta T, Lipińska B, Grzywa R, Sieńczyk M, Rolka K, Lesner A. Design and synthesis of new substrates of HtrA2 protease. Anal Biochem
2014
Guarino C, Legowska M, Epinette C, Kellenberger C, Dallet-Choisy S, Sieńczyk M, Gabant G, Cadene M, Zoidakis J, Vlahou A, Wysocka M, Marchand-Adam S, Jenne DE, Lesner A, Gauthier F, Korkmaz B. New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases. J Biol Chem. 2014 Nov 14;289(46):31777-91.
Wang J, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C,Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta. 2014 Nov;1842(11):2174-83.
Wang J, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT, Shi GP. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. J Vasc Surg. 2014 Jul 16. pii: S0741-5214(14)01115-X.
Dębowski D, Pikuła M, Lubos M, Langa P, Trzonkowski P, Lesner A, Łęgowska A, Rolka K. Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1. PLoS One. 2014 Feb 25;9(2):e89465.
Figaj D, Gieldon A, Polit A, Sobiecka-Szkatula A, Koper T, Denkiewicz M, Banecki B, Lesner A, Ciarkowski J, Lipinska B, Skorko-Glonek J. The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies. J Biol Chem. 2014 May 30;289(22):15880-93.
Burchacka E, Sienczyk M, Frick IM, Wysocka M, Lesner A, Oleksyszyn J. Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro. Biochimie. 2014 Aug;103:137-43.
Lęgowska M, Wysocka M, Burster T, Pikuła M, Rolka K, Lesner A. Ultrasensitive internally quenched substrates of human cathepsin L. Anal Biochem. 2014 Aug 23. pii:S0003-2697(14)00343-1.
Grzywa R, Gorodkiewicz E, Burchacka E, Lesner A, Laudański P, Lukaszewski Z, Sieńczyk M. Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor wiyh tailored phosphonic inhibitor. Eur J Obstet Gynecol Reprod Biol. 2014 Aug 29;182C:38-42.
Grzywa R, Burchacka E, Lęcka M, Winiarski L, Walczak M, Lupicka-Słowik A, Wysocka M, Burster T, Boberek K, Csencsits-Smith K, Lesner A, Sieńczyk M. Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms. Chembiochem. 2014 Sep 18. doi: 10.1002/cbic.201402360.
Wysocka M, Gruba N, Miecznikowska A, Popow-Stellmaszyk J, Gütschow M, Stirnberg M, Furtmann N, Bajorath J, Lesner A, Rolka K. Substrate specificity of human matriptase-2. Biochimie. 2014 Feb;97:121-7.
Lesner A, Karna N, Psurski M, Lęgowska A, Wysocka M, Guzow K, Sieradzan A,Sieńczyk M, Trzonkowski P, Pikuła M, Zieliński M, Kosikowska P, Lukajtis R,Lęgowska M, Dębowski D, Wiczk W, Rolka K. Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds-synthesis and applications. Biopolymers. 2014 Jan;102(1):124-35.
2013
Kosikowska P, Lesner A. Inhibitors of cathepsin G: a patent review (2005 to present). Expert Opin Ther Pat. 2013 Dec;23(12):1611-24.
Popow-Stellmaszyk J, Wysocka M, Lesner A, Korkmaz B, Rolka K. A new proteinase 3 substrate with improved selectivity over human neutrophil elastase. Anal Biochem. 2013 Nov 1;442(1):75-82.
Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Viaud-Massuard MC, Jenne DE, Gauthier F. Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis). Semin Immunopathol. 2013 Jul;35(4):411-21.
Debowski D, Lukajtis R, Filipowicz M, Strzelecka P, Wysocka M, Lęgowska A, Lesner A, Rolka K. Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines. Biopolymers. 2013 Apr;100(2):154-9.
Zurawa-Janicka D, Jarzab M, Polit A, Skorko-Glonek J, Lesner A, Gitlin A,Gieldon A, Ciarkowski J, Glaza P, Lubomska A, Lipinska B. Temperature-induced changes of HtrA2(Omi) protease activity and structure. Cell Stress Chaperones. 2013 Jan;18(1):35-51
Lesner A. Proteolysis in health and disease. Curr Pharm Des. 2013;19(6):965.
Wysocka M, Lesner A. Future of protease activity assays. Curr Pharm Des. 2013;19(6):1062-7.
Zdzalik M, Kalinska M, Wysocka M, Stec-Niemczyk J, Cichon P, Stach N, Gruba N, Stennicke HR, Jabaiah A, Markiewicz M, Kedracka-Krok S, Wladyka B, Daugherty PS, Lesner A, Rolka K, Dubin A, Potempa J, Dubin G. Biochemical and structural characterization of SplD protease from Staphylococcus aureus. PLoS One. 2013 Oct 9;8(10):e76812.
2012
Wysocka M, Lesner A, Popow J, Łegowska M, Rolka K. Pegylated fluorescent peptides as substrates of proteolytic enzymes. Protein Pept Lett. 2012 Dec;19(12):1237-44.
Wysocka M, Lesner A, Gruba N, Korkmaz B, Gauthier F, Kitamatsu M, Łęgowska A, Rolka K. Three wavelength substrate system of neutrophil serine proteinases. Anal Chem. 2012 Aug 21;84(16):7241-8.
Dębowski D, Łukajtis R, Łęgowska A, Karna N, Pikuła M, Wysocka M, Maliszewska I, Sieńczyk M, Lesner A, Rolka K. Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin. Peptides. 2012 Jun;35(2):276-84.
Gorodkiewicz E, Sieńczyk M, Regulska E, Grzywa R, Pietrusewicz E, Lesner A, Lukaszewski Z. Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications. Anal Biochem. 2012 Apr 15;423(2):218-23.
Kalińska M, Kantyka T, Greenbaum DC, Larsen KS, Władyka B, Jabaiah A, Bogyo M, Daugherty PS, Wysocka M, Jaros M, Lesner A, Rolka K, Schaschke N, Stennicke H, Dubin A, Potempa J, Dubin G. Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C. Biochimie. 2012 Feb;94(2):318-27.
2011
Lesner A, Łęgowska A, Wysocka M, Rolka K. Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery. Curr Pharm Des. 2011 Dec;17(38):4308-17.
Łęgowska A, Dębowski D, Łukajtis R, Sztabkowska E, Mizeria A, Brzozowski K,Wysocka M, Lesner A, Rolka K. Introduction of Pro and its analogues in the conserved P1' position of trypsin inhibitor SFTI-1 retains its inhibitory activity. Protein Pept Lett. 2011 Nov;18(11):1158-67.
2010
Lęgowska A, Dębowski D, Lukajtis R, Wysocka M, Czaplewski C, Lesner A, Rolka K. Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases. Bioorg Med Chem. 2010 Dec 1;18(23):8188-93.
Legowska A, Bulak E, Jaśkiewicz A, Małuch I, Sieracki M, Wysocka M, Lesner A, Rolka K. Analogues of trypsin inhibitor SFTI-1 with disulfide bridge substituted by various length of carbonyl bridges. Protein Pept Lett. 2010 Oct;17(10):1223-7.
Wysocka M, Spichalska B, Lesner A, Jaros M, Brzozowski K, Łegowska A, Rolka K. Substrate specificity and inhibitory study of human airway trypsin-like protease. Bioorg Med Chem. 2010 Aug 1;18(15):5504-9.
Wysocka M, Lesner A, Guzow K, Kulczycka J, Łegowska A, Wiczk W, Rolka K. Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum. Anal Chem. 2010 May 1;82(9):3883-9.
Łegowska A, Lesner A, Bulak E, Jaśkiewicz A, Sieradzan A, Cydzik M, Stefanowicz P, Szewczuk Z, Rolka K. Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing. FEBS J. 2010 May;277(10):2351-9.
Wysocka M, Lesner A, Majkowska G, Legowska A, Guzow K, Rolka K, Wiczk W. The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region. Anal Biochem. 2010 Apr 15;399(2):196-201.
Łegowska A, Debowski D, Lesner A, Wysocka M, Rolka K. Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach. Mol Divers. 2010 Feb;14(1):51-8.