Publikacje

2014

• Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL, Day R. (2014) Design, Synthesis, and Structure-Activity Relationship Studies of a Potent PACE4 Inhibitor. J Med Chem. 57(1):98-109.

2013

• Sikorska E, Kwiatkowska A. (2013) Micelle-bound conformations of neurohypophyseal hormone analogues modified with a Cα-disubstituted residue: NMR and molecular modelling studies. J Biomol Struct Dyn. 31(7):748-64.

2012

• Levesque C, Fugère M, Kwiatkowska A, Couture F, Desjardins R, Routhier S, Moussette P, Prahl A, Lammek B, Appel JR, Houghten RA, D'Anjou F, Dory YL, Neugebauer W, Day R. (2012) The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J Med Chem. 55(23):10501-11.

• Podstawka-Proniewicz E, Sobolewski D, Prahl A, Kim Y, Proniewicz LM. (2012) Structure and conformation of Arg⁸ Vasopressin Modified Analogs", J. Raman Spectrosc. 43: 51-60.

• Sikorska E, Iłowska E, Wyrzykowski D, Kwiatkowska A. (2012) Membrane structure and interactions of peptide hormones with model lipid bilayers. Biochim Biophys Acta. 1818:2982-2993.

• Kamysz E, Sikorska E, Karafova A, Dawgul M. (2012) Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5. J Pept Sci. 18(9): 560-6.

• Peredih A., Choudhury A.R., Župerl Š., Sikorska E., Zhukov I., Solmajer T., Novic M. (2012) Structural analysis of a peptide fragment of transmembrane transporter protein bilitranslocase. PLoS ONE 7(6): e38967. doi:10.1371/journal.pone.0038967

• Lubecka E.A., Ciarkowski J., Prahl A., Sikorska E. (2012) Highly potent antidiuretic antagonists: conformational studies of vasopressin analogues modified with 1-naphthylalanine enantiomers at position 2. Chem. Biol. Drug Des. 79(6):1033-42

• Sikorska E., Sobolewski D., Kwiatkowska A. (2012) Conformational preferences of proline derivatives incorporated into vasopressin analogues: NMR and molecular modelling studies. Chem. Biol. Drug Des. 79(4):535-47

2011

• Podstawka-Proniewicz E., Sobolewski D., Prahl A., Kim Y., Proniewicz L.M. (2011) Structure and conformation of Arg8 vasopressin modified analogs., J. Raman Spectr., DOI 10.1002/jrs.2986, 2011.

• Mrozek J., Guzow K., Sikorska E., Wiczk W. (2011) Influence of amino acid sequence on the interaction of short peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]-alanine with β-cyclodextrin. Cent. Eur. J. Chem. 9: 1046-1055.

• Ciarkowski J., Łuczak S., Jagieła D., Sikorska E., Wójcik J., Oleszczuk M., Izdebski J. (2011) Ensemble fits of restrained peptides’ conformational equilibria to NMR data. Dependence on force fields: AMBER/8 ff03 versus ECEPP/3. J. Mol. Graph Model. 32: 67-74.

• Kwiatkowska A, Ptach M, Borovičková L, Slaninová J, Lammek B, Prahl A. (2011) Design, synthesis and biological activity of new neurohypophyseal hormones analogues conformationally restricted in the N-terminal part of the molecule. Highly potent OT receptor antagonists. Amino Acids. DOI: 10.1007/s00726-011-1109-6.

• Sleszyńska M, Wierzba TH, Malinowski K, Borovičková L, Małuch I, Sobolewski D, Lammek B, Slaninová J, Prahl A. (2011) Novel analogues of bradykinin conformationally restricted in the C-terminal part of the molecule. J Pept Sci. 2011 May;17(5):366-72

2010

• Kwiatkowska A, Sleszyńska M, Derdowska I, Prahl A, Sobolewski D, Borovicková L, Slaninová J, Lammek B. (2010) "Novel analogues of arginine vasopressin containing alpha-2-indanylglycine enantiomers in position 2." J Pept Sci. 16:15-20.

• Kamysz E, Sikorska E. (2010) Synthesis and conformational analysis of salivary proline-rich peptide P-B. J. Pept. Sci. DOI: 10.1002/psc.1297.

• Lubecka E., Kwiatkowska A., Ciarkowski J., Sikorska E. (2010) NMR studies of new arginine vasopressin analogs modified with alpha-2-indanylglycine enantiomers at position 2 bound to sodium dodecyl sulfate micelles. Biophys Chem. 151: 139-48.

• Sikorska E., Kwiatkowska A., Sobolewski D., Ślusarz R., Ślusarz MJ. Influence of bulky 3,3'-diphenylalanine enantiomers replacing position 2 of AVP analogues on their conformations: NMR and molecular modeling studies. (2010) Eur J Med Chem. 45:4065-73.

• Jankowska E., Gaczyńska M., Osmulski P., Sikorska E., Rostankowski R., Madabhushi S., Tokmina-Łukaszewska M., Kasprzykowski F. (2010) Potential allosteric modulators of the proteasome activity. Biopolymers 93: 481-498.

• Rodziewicz-Motowidło S., Mickiewicz B., Greber K., Sikorska E., Szultka L., Kamysz E., Kamysz W. (2010) Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide. FEBS J. 277: 1010-1022.

2009

• Śleszyńska M, Kwiatkowska A, Sobolewski D, Wierzba TH, Katarzyńska J, Zabrocki J, Borovickova L, Slaninová J, Prahl A. (2009) New bradykinin B(2) receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties. Acta Biochim Pol. 56:641-8.

• Kwiatkowska A, Sobolewski D, Prahl A, Borovicková L, Slaninová J, Lammek B. (2009) "Arginine vasopressin and its analogues--the influence of position 2 modification with 3,3-diphenylalanine enantiomers. Highly potent V2 agonists." Eur J Med Chem. 44: 2862-67.

• Bélanger S., Bovenzi V., Côté J., Neugebauer W., Amblard M., Martinez J., Lammek B., Savard M., Gobeil F.Jr. (2009) "Structure-activity relationships of novel peptide agonists of the human bradykinin B2 receptor.", Peptides, 30(4): 777-87.

• Sobolewski D., Prahl A., Kwiatkowska A., Slaninová J., Lammek B. (2009) "Analogues of AVP modified in the N-terminal part of the molecule with Pip isomers: TFA-catalysed peptide bond hydrolysis.", J. Pept Sci., 15(3): 161-5.

2008

• Barinka C., Prahl A., Lubkowski J. (2008) "Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).", Acta Crystallogr. D Biol. Crystallogr., 64(3): 273-8.

• Sikorska E., Rodziewicz-Motowidło S. (2008) "Conformational studies of vasopressin and mesotocin using NMR spectroscopy and molecular modelling methods. Part I: studies in water.", J Pept. Sci., 14(1), 76-84.

• Rodziewicz-Motowidło S., Sikorska E., Oleszczuk M., Czaplewski C. (2008) "Conformational studies of vasopressin and mesotocin using NMR spectroscopy and molecular modelling methods. Part II: studies in the SDS micelle.", J Pept. Sci., 14(1): 85-96.

• Sikorska E., Rodziewicz-Motowidło S. (2008) "Solution conformations of bradykinin antagonists modified with Cα-Cα cyclized nonaromatic residues", J. Pept. Sci.: 14(7), 819-29.

• Rodziewicz-Motowidło S., Czaplewska P., Sikorska E., Spodzieja M., Kołodziejczyk A.S. (2008) "The Arctic mutation alters helix length and type in the 11-28 ?-amyloid peptide monomer-CD, NMR and MD studies in an SDS micelle.", J. Struct. Biol., 164, 199-209.

• Mrozek J., Banecki B., Sikorska E., Skwierawska A., Karolczak J., Wiczk W. (2008) "Influence of the substituent on amide nitrogen atom of N-acetyl tyrosine on interactions with cyclodextrin.", Chem. Phys., 354, 58-70.

• Ślusarz R., Sikorska E., Ślusarz M.J. (2008) "Theoretical study on interactions of bicyclic vasopressin analogues with human neurohypophyseal hormone receptors.", QSAR Comb. Sci., 27, 834-40.

2007

• Podstawka E., Sikorska E., Proniewicz L.M., Lammek B. (2007) "Raman and surface-enhanced Raman spectroscopy investigation of vasopressin analogues containing 1-aminocyclohexane-1-carboxylic acid residue." Biopolymers, 83(2): 193-203 (2006). Erratum in: Biopolymers, 85(5-6): 498.

• Kowalczyk W., Prahl A., Derdowska I., Sobolewski D., Olejnik J., Zabrocki J., Borovicková L., Slaninová J., Lammek B. (2006) "Analogues of Neurohypophyseal Hormones, Oxytocin and Arginine Vasopressin, Conformationally Restricted in the N-Terminal Part of the Molecule.", J. Med. Chem., 49(6): 2016-21.

• Labudda O., Wierzba T., Sobolewski D., Kowalczyk W., Śleszyńska M., Gawinski L., Plackova M., Slaninova J., Prahl A. (2006) "New bradykinin analogues substituted in positions 7 and 8 with sterically restricted 1-aminocyclopentane-1-carboxylic acid.", J. Pept. Sci., 12(12): 775-9.

• Sobolewski D., Prahl A., Derdowska I., Slaninova J., Kaczmarek K., Zabrocki J., Lammek B. (2006) "Analogs of arginine vasopressin modified in the N-terminal part of the molecule with a conformationally constrained cis-peptide bond motif.", J. Pept. Sci., 13(2): 128-32.

• Prahl A. (2006) " Modifications in the bradykinin main chain are not necessary for antagonistic activity in rat blood pressure assay.", J. Pept. Sci., 13(3): 206-10.

• Labudda O., Wierzba T., Sobolewski D., Śleszyńska M., Gawiński Ł., Plackowa M., Slaninova J., Prahl A. (2007) "New bradykinin analogues acylated on the N-terminus: effect on rat uterus and blood pressure.", Acta. Biochim. Pol., 54(1): 193-7.

• Pazgier M., Prahl A., Hoover D.M., Lubkowski J. (2007) "Studies of the biological properties of human beta-defensin.", J. Biol. Chem., 282(3): 1819-29.

• Sobolewski D., Prahl A., Derdowska I., Kwiatkowska A., Slaninová J., Lammek B. (2007) "Influence of conformationally constrained amino acids replacing positions 2 and 3 of arginine vasopressin (AVP) and its analogues on their pharmacological properties", Prot. Pept. Lett., 14(3): 213-217.

2006

• Sikorska E., Ślusarz M.J., Ślusarz R., Kowalczyk W., Lammek B. (2006) "Investigation of cis/trans ratios of peptide bonds in AVP analogues containing N-methylphenylalanine enantiomers.", J. Pept. Sci., 12(1):13-24.

• Sikorska Trzepalka E., Slusarz R., Lammek B. (2006) "Conformational studies of two bradykinin antagonists by using two-dimensional NMR techniques and molecular dynamics simulations.", J. Biomol. Struct. Dyn., 23(2): 125-34.

• Śmiech B., Kazmierkiewicz R., Lammek B. (2006) "The influence of modification at position 2 on the side-chain conformation in oxytocin analogs." Acta Biochim. Pol. 53(1): 113-20.

• Kowalczyk W., Prahl A., Derdowska I., Sobolewski D., Olejnik J., Zabrocki J., Borovickova L., Slaninova J., Lammek B. (2006) "Analogues of neurohypophyseal hormones, oxytocin and arginine vasopressin, conformationally restricted in the N-terminal part of the molecule." J. Med. Chem., 49(6): 2016-21.

2005

• Derdowska I., Prahl A., Kowalczyk W., Janecki M., Malhem S., Trzeciak H.I., Lammek B. (2005) "Influence of Enantiomers of 1-Naphtylalanine in Position 2 of AVP and dAVP on their Pharmacological Properties.", Eur. J. Med. Chem., 40(1): 63-8

• Sobolewski D., Kowalczyk W., Derdowska I., Slaninova J., Kaczmarek K., Zabrocki J., Lammek B. (2005) "Analogues of Arginine Vasopressin (AVP) Modified in the N-terminal Part of the Molecule with Stereoisomers of 4-Aminopyroglutamic Acid.", Polish J. Chem., 79(4): 731-7.

• Sobolewski D., Kowalczyk W., Prahl A., Derdowska I., Slaninova J., Zabrocki J., Lammek B. (2005). "Analogues of Arginine Vasopressin (AVP) and its Agonist and Antagonist Modified in the N-terminal Part of the Molecule with L- -Homophenylalanine.", J. Pept. Res., 65(4): 465-71.

• Dawidowska O, Prahl A, Wierzba T, Nowakowski L, Kowalczyk W, Slaninova J, Lammek B. (2005) "New acylated bradykinin analogues: effect on rat blood pressure and rat uterus.", J. Pept. Sci.,, 11(7): 436-9.

• Kowalczyk W, Prahl A, Dawidowska O, Derdowska I, Sobolewski D, Hartrodt B, Neubert K, Slaninova J, Lammek B. (2005) "The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties.", J. Pept. Sci., 11(9): 584-8.

• Sikorska Trzepałka E., Ślusarz R., Lammek B. (2005) "Conformational studies of two bradykinin antagonists by using two-dimensional NMR techniques and molecular dynamics simulations.", J. Biomol. Struct. Dyn., 23(2): 125-34.

• Labudda-Dawidowska O., Wierzba T.H., Prahl A., Kowalczyk W., Gawiński L., Plackowa M., Slaninova J., Lammek B. (2005) "New bradykinin analogues modified in the C-terminal part with sterically restricted 1-aminocyclohexane-1-carboxylic acid.", J. Med. Chem., 48(25): 8055-9.

• Sikorska E., Slusarz R., Lammek B. (2005) " Conformational studies of highly potent 1-aminocyclohexane-1-carboxylic acid substituted V vasopressin agonists." J. Pept. Res., 66 Suppl 1: 30-40.

2004

• Dawidowska O., Prahl A., Kowalczyk W., Derdowska I., Neubert K., Zabrocki J., Olejniczak B., Wierzba T., Juzwa W., Lammek B. (2004) "Potent bradykinin antagonists containing in position 8 N-benzylglycine or N-benzyl-L-alanine.", J. Pept. Res., 63(1): 29-35.

• Trzepałka E., Kowalczyk W., Lammek B. (2004), "Cis/Trans Conformational equilibrium across the N-methylphenylalanine2-N-methylphenylalanine3 peptide bond of arginine vasopressin analogues", J. Pept. Res., 63(4): 333-46.

• Kowalczyk W., Derdowska I., Dawidowska O., Prahl A., Hartrodt B., Neubert K., Slaninova J., Lammek B. (2004) "Analogues of Arginine Vasopressin Modified in the N-Terminal Part of the Molecule with Enantiomers of N-Methylphenylalanine", J. Pept. Res., 63(5): 420-5.

• Trzepałka E., Oleszczuk M., Maciejczyk M., Lammek B. (2004) "Structure determination of vasopressin analogues conformationally restricted in the N-terminal part of the molecule in aqueous solution using NMR", Acta Biochim. Pol. , 51(1): 33-49.

• Kowalczyk W., Prahl A., Derdowska I., Dawidowska O., Slaninová J., Lammek B. (2004) "Highly potent 1-aminocyclohexane-1-carboxylic acid substituted V2 agonists of arginine vasopressin.", J. Med. Chem., 47(24): 6020-4.

• 20. Łempicka E., Derdowska I., Kowalczyk W., Dawidowska O., Prahl A., Janecki M., Jasiński T., Trzeciak H.I., Lammek B. (2004) "Analogues of Arginine Vasopressin Modified in Position 2 and 3 with Conformationally Constrained Dipeptide Fragments.", J. Pept. Sci.,, 11(2): 91-6.

2003

• Chruścińska E., Derdowska I., Kozłowski H., Lammek B., Łuczkowski M., Ołdziej S., Świątek-Kozłowska J. (2003) "Unusual gain in the coordination ability of vasopressin-like peptides towards Cu2+ ions by insertion of the highly hydrophobic side chain.", New Journal of Chemistry , 27(2): 251-6.

• Jastrzębska B., Derdowska I., Kowalczyk W., Machova A., Slaninowa J., Lammek B. (2003) "Influence of 1-aminocycloheksane-1-carboxylic acid in position 2 or 3 of AVP and its analogues on their pharmacological properties.", J. Pept. Res., 62(2): 70-7.

• Prahl A., I. Derdowska, O. Dawidowska, K. Neubert, B. Hartrodt, T. Wierzba W., Juzwa, Lammek B. (2003) "New bradykinin analogues substituted in positions 6 and 7 with naphthylalanine.", Polish J. Chem., 77: 881-7.

• Ślusarz R., Ślusarz M.J., Kaźmierkiewicz R., Lammek B. (2003), "Molecular modeling of interaction of the vasopressin analogs with vasopressin and oxytocin receptors.", QSAR Comb. Sci., 22(8): 865-72.

2002

• Jastrzębska B., Derdowska I., Kuncarowa P., Slaninova J., Lammek B., Olejniczak B., Zabrocki J. (2002) "Analogues of arginine vasopressin (AVP) modified in the N- terminal part of the molecule with N-benzylglycine.", Polish J. Chem., 76(6): 823-30.

• Prahl A., Derdowska I., Dawidowska O., Neubert K., Hartrodt B., Wierzba T., Juzwa W., Lammek B. (2002) "New analogues of bradykinin substituted in the C-terminal part of the molecule with naphthylalanine.", Polish J. Chem., 76(10): 1433-9.

• Prahl A., Wierzba T., Derdowska I., Juzwa W., Neubert K., Hartrodt B., Lammek B. (2002) "New bradykinin analogues substituted in positions 6 and 7 with enantiomers of N-methylphenylalanine.", Polish J. Chem., 76(5): 713-9.

• Prahl A., Derdowska I., Dawidowska O., Neubert K., Hartrodt B., Wierzba T., Juzwa W. Lammek B. (2002) "New analogues of bradykinin substituted in the C-terminal part of the molecule with naphthylalanine.", Polish J. Chem., 76(10): 1433-9.

2001

• Derdowska I., Prahl A., Neubert K., Hartrodt B., Kania A., Dobrowolski D., Melhem S., Trzeciak H. I., Wierzba T., Lammek B. (2001) "New analogues of bradykinin containing a conformationally restricted dipeptide fragment in their molecules.", J. Pept. Res., 57(1): 11-8.

• Łempicka E., I. Derdowska, B. Jastrzębska, P. Kuncarova, J. Slaninova and B. Lammek (2001). "Analogs of oxytocin conformationally restricted in the N- terminal part of the molecule.", J. Pept. Res., 57(2): 162-7.

• Ślusarz R., Kaźmierkiewicz R., Giełdon A., Lammek B., Ciarkowski J. (2001) "Molecular docking-based test for affinities of two ligands toward vasopressin and oxytocin receptors." Acta Biochim. Pol. 48(1): 131-5.

2000

• Ślusarz R., Kaźmierkiewicz R., Lammek B. (2000) "Theoretical conformational analysis of six arginine vasopressin analogs with the L-naphthylalanine in position 3.", J. Pept. Res., 56(6): 352-9.

• Sobocińska M., Łempicka E., Konieczna E., Derdowska I., Lammek B., Melhem S., Kozik W., Janecka J., Janecki M., Trzeciak H. I. (2000) "Analogues of arginine vasopressin modified in position 2 or 3 with naphthylalanine: Selective antagonists of oxytocin in- vitro.", J. Pharm. Pharmacol., 52(9): 1105-12.

• Trzeciak H. I., Kozik W., Melhem S., Kania A., Dobrowolski D., Prahl A., Derdowska I., Lammek B. (2000) "New bradykinin analogs in contraction of rat uterus.", Peptides, 21(6): 829-34.