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Publikacje 2000-2005



1. Lesner A, Li Y, Nitkiewicz J, Li G, Kartvelishvili A, Kartvelishvili M, Simm M., A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer, J Immunol. 175, 2548-2554(2005).

2. Lesner A. Rolka K., Structure-activity-relationship studiem of synthetic serie proteinase inhibitors and substrates based on the sequence of trypsin inhibitors isolated from squash and sunflower seeds, Recent Res. Plant Sci. 3, 105(2005).

3. Stawikowski M, Stawikowska R, Jaśkiewicz A, Zabłotna E, Rolka K. Examples of peptide-peptoid hybrid serine protease inhibitors based on the trypsin inhibitor SFTI-1 with complete protease resistance at the P1-P1' reactive site, Chembiochem. 6, 1057-1061 (2005).

4. Kotlinska J, Rafalski P, Talarek S, Dylag T, Rolka K, Wichmann J, Silberring J. Is the nociceptin (NOP) receptor involved in attenuation of the expression of sensitization to morphine-induced hyperlocomotion in mice?, Behav Pharmacol. 16, 101-106(2005).


1. Kartvelishvili A, Lesner A, Szponar M, Simm M., Microarray analysis of differentially expressed genes in cells resistant to HIV-1., Immunol Lett., 93, 79-86(2004).

2. Klaudel L., Łęgowska A., Brzozowski K., Silberring J., Wójcik J., Rolka K., Solution Conformational Study of Nociceptin and its 1-13 and 1-11 Fragments Using Circular Dichroism and Two-dimensional NMR in Conjuncjon with Theoretical Conformational Ananlysis, J. Pept. Sci., 10, 678-690 (2004).

3. Zabłotna E., Dysasz H., Lesner A., Jaśkiewicz A., Kaźmierczak K., Miecznikowska H., Rolka K., A Simple Method for Selection of Trypsin Chromogenic Substrates Using Combinatorial Chemistry Approach, Biochem. Biophys. Res. Commun., 319, 185-188 (2004).

4. Valensin D., Łuczkowski M., Mancini F. M., Łęgowska A., Gaggelli E., Valnsin G., Rolka K., Kozłowski H., The dimeric and tetrameric Octarepeat Fragments of Prion Protein Behave Differentl to Its Monomeric Unit, J. Chem. Soc. Dalton Trans., 1284-1293 (2004).

5. Lesner A, Kartvelishvili A, Lesniak J, Nikolov D, Kartvelishvili M, Trillo-Pazos G, Zablotna E, Simm M., Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1, Biochemistry., 43, 16203-16211(2004).


1. Bereset V., Rutkowski M., Rolka K., Łęgowska A., Dębska G., Stępkowski D., Szewczyk A., The Prion Peptide Forms Ion Chanells in Plana Lipid Bilayers, Cell. Mol. Biol. Lett., 8, 353-362 (2003).

2. Okrój M., Dobrzańska-Paprocka Z., Rolka K., Bigda J., In vivo and In vitro Analysis of Biological Activity of RGD Peptides Towards AB Bomirski Melanoma , Cell. Mol. Biol. Lett., 8, 873-884 (2003).

3. Suder P., Bogusiewicz A., Rolka K., Laidler P., Kotlińska J., Silberring J., Rat Neuronal Cells in Primary Culture as a Model for Nociceptin/Orphanin FQ Metabolism, Neuroscience Lett. 348, 167-170 (2003).

4. Kotlińska J., Rafalski P., Biela G., Dylag T., Rolka K., Silberring J., Nociceptin Inhibits Acquisitation of Amphetamine-Induced Place Preference and Sensitization to Stereotypy in Rats, Eur. J. Pharmacol., 474, 233-239 (2003).

5. Kaźmierczak K., Zabłotna E., Jaśkiewicz A., Miecznikowska H., Rolka K.,Selection of Low-Molecular mass Trypsin and Chymotrypsin Inhibitors Based on the Binding Loop of CMTI-III using Combinatorial Chemistry Approach, Biochem. Biophys. Res. Commun., 310, 811-815 (2003).


1. Frąszczak P., Rolka K., Kupryszewski G., New Analogues of Cucurbita maxima Trypsin Inhibitor (CMTI-III) Substituted with D-Arg or D-Lys in Position 5 (P1), Polish J. Chem., 76, 519-523 (2002).

2. Rodziewicz-Motowidło S., Brzozowski K., Łęgowska A., Liwo A., Silberring J., Smoluch M., Rolka K., Conformational Solution Studies of Neuropeptide Using CD and NMR Spectroscopy, J. Pept. Sci., 8, 211-226 (2002).

3. Zabłotna E., Kaźmierczak K., Jaśkiewicz A., Stawikowski M., Kupryszewski G., Rolka K., Chemical Synthesis and Kinetic Study of the Smallest Naturally Occurring Trypsin Inhibitor SFTI-1 Isolated from Sunflower Seeds and Its Analogues, Biochem. Biophys. Res. Commun., 292, 855-859 (2002).

4. Łuczkowski M., Kozłowski H., Stawikowski M., Rolka K., Gaggelli E., Valensin D., Valensin G., Is a Monomeric Prion Octapeptide Repeat PHGGGWGQ specific ligand for Ca2+ Ions?, J. Chem. Soc. Dalton Trans., 2269-2274 (2002).

5. Kotlińska J., Wichmann J., Łęgowska A., Rolka K., Silberring J., Orphanin Q/Nociceptin But Not Ro 65-6570 Inhibits the Expression of Cocaine Induced Conditioned Place Preference, Behav. Pharmacol, 13, 229-235 (2002).

6. Brzozowski K., Łęgowska A., Rodziewicz-Motowidło S., Liwo A., Rolka K., The Study of Conformational Equilibrium of c[Gln-Phe-Gly-Leu-Met], a NK-2 Tachykinin Antagonist, Polish J. Chem., 76, 807-814 (2002).

7. Simm M, Miller LS, Durkin HG, Allen M, Chao W, Lesner A, Potash MJ, Volsky DJ., Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection., Virology. 294, 1-12(2002).

8. Frąszczak P., Kaźmierczak K., Stawikowski M., Jaśkiewicz A., Kupryszewski G., Rolka K., Analogues of Ecballium elaterium Trypsin Inhibitor II (EETI-II) with L-Cysteine Residues Substituted by L-Penicillamine (PEN) and L-Homocysteine in Positions 19, 21 and 27, Polish J. Chem., 76, 1441-1446 (2002).

9. Zabłotna E., Kaźmierczak K., Jaśkiewicz A., Kupryszewski G., Rolka K., Inhibition of bovine ?-chymotrypsin by cyclic trypsin inhibitor SFTI-1 isolated from sunflower seeds and its two acyclic analogues, LIPS, 9, 131-134 (2002).

10. Łuczkowski M., Kozłowski H., Łęgowska A., Rolka K., Remelli M., The Possible Role of Gly Residues in the Prion Octarepeat Region in the Coordination of Cu2+ Ions, J. Chem. Soc. Dalton Trans., 619-624, (2003).


1. Karawajczyk B., Wirkus-Romanowska I., Wysocki J., Rolka K., Maćkiewicz Z., Głośnicka R., Kupryszewski G., Cyclic Analogue of Human Heat Shock Protein 70(29-42) Frgment. Synthesis, Conformational Studies and Evaluation of Its Immunogenicity, Polish J. Chem., 75, 265-273 (2001).

2. Kotlińska J., Suder P., Sciubisz A., Łęgowska A., Eilmes J., Rolka K., Silberring J., C-Terminal Glycine is Crucial for Hyperalgesic Activity of Nociceptin/Orphanin FQ-(1-6), Eur. J. Pharmacol., 419, 33-37 (2001).

3. Rodziewicz-Motowidło S., Lesner A., Łęgowska A., Czaplewski C., Liwo A., Rolka K., Patacchini R., Laura Q., Synthesis, Activity on NK-3 Tachykinin Receptor and Conformational Studies of Scyliorhinin II Analogues Modified in Position 13, J. Pept. Res., 58, 159-172 (2001).

4. Lesner A., Kupryszewski G., Rolka K., Chromogenic Substrates of Bovine -trypsin: The Influence of an amino Acid Residue in P1 Position on Their Interaction with the Enzyme, Biochem. Biophys. Res. Commun., 285, 1350-1353 (2001).

5. Suder P., Wade D., Łęgowska A., Kotlińska J., Rolka K., Silberring J., Dynorphin A Inhibits Nociceptin-Converting Enzyme from the Rat Spinal Cord., Biochem. Biophys. Res. Commun., 287, 927-931 (2001).

6. Frąszczak P., Lis K., Jaśkiewicz A., Miecznikowska H., Rolka K., Kupryszewski G., Low Molecular Mas Inhibitors of Bovine -Trypsin Containing Binding Loop of CMTI-III. Synthesis and Evaluation of Inhibitory Activity, Polish J. Chem., 75, 1863-1868 (2001).


1. Kotlińska J., Suder P., Łegowska A., Rolka K., Silberring J., Orphanin FQ/Nociceptin Inhibits Morphine Withdrowal, Life Sci. 66, 119-123 (2000) .

2. Lesner A., Brzozowski K., Kupryszewski G., Rolka K., Design, Chemical Synthesis and Kinetic Studies of Trypsin Chromogenic Substrates Based on the Proteinase Binding Loop of Cucurbita maxima Trypsin Inhibitor (CMTI-III), Biochem. Biophys. Res. Commun., 269, 81-84 (2000).

3. Rodziewicz-Motowidło S., Łęgowska A., Qi X.-F., Czaplewski C., Liwo A., Sowiński P., Mozga W., Olczak J., Zabrocki J., Rolka K., Solution Conformational Study of Scyliorhinin I Analogues with Conformational Constrains by 2D NMR and Theoretical Conformational Analysis, J. Pept. Res., 56, 132-146 (2000).

4. Klaudel L., Rodziewicz-Motowidło S., Liwo A., Rolka K., A Comparison of Solution Conformations of Scyliorhinin I and Its Analogue with N-methyl-L-Phenylalanine in Position 7, Pol. J. Chem., 74, 1091-1099 (2000).

5. Wirkus-Romanowska I.,Rodziewicz-Motowidło S., Miecznikowska H., Rolka K., Janusz M., Szymaniec S., Zabłocka A., Fortuna W., Międzybrodzki R., Lisowski J., Kupryszewski G., Cyclic Analogues of Proline Rich Protein Fragments. Part III. Synthesis of New Analogues, Conformational Studies and Evaluation of Immunotropic Activity, Pol. J. Chem., 74, 1129-1141 (2000).

6. Suder P., Kotlińska J., Łęgowska A., Smoluch M., Höhne G., Chervet J.-P., Rolka K., Silberring J., Determination of Nociceptin-Orphanin FQ Metabolites by Capillary LC-MS, Brain Res. Prot. 6, 40-46 (2000).

Treść ostatnio zmodyfikowana przez: Agata Gitlin
Treść wprowadzona przez: Agata Gitlin
Ostatnia modyfikacja: 
poniedziałek, 13 stycznia 2014 roku, 13:21