COST CM1206: "Exchange on ionic liquids"

Working group 4 has currently 23 members from 10 different countries. The research areas of the members is mainly focued on toxicity, ecotoxicity and bioaccemulation stuides of ionic liquids. WG4 is also focusing on scale up challengers as well as comercial exploitation of ionic liquids.


Gender Balance                         Origin of the Members

malefemalenofill krajenofill

Meet the leaders of WG4:


Peer-reviewed results:    


Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans

P.C. Alves, D.O. Hartmann, O. Núñez, I. Martins, T.L. Gomes, H. Garcia, M.T. Galceran, R. Hampson, J.D. Becker, C. Silva Pereira, BMC Genomics (2016) 17(1): 284

Efficiency of hydrophobic phosphonium ionic liquids and DMSO as recyclable cellulose dissolution and regeneration media

A.J. Holding,  A. Parviainen,  I. Kilpeläinen,  A. Soto, A.W.T. King,  H. Rodríguez, RSC Adv. (2017) 7:17451–17461

Saccharification of lignocellulosic biomasses via ionic liquid pretreatment

T. Aid, S. Hyvärinen, M. Vaher, M. Koel, J.-P. Mikkola, Ind. Crop. Prod. (2016) 92:336–341

Eutectic mixtures of pyrrolidinium-based ionic liquids

O. Stolarska, H. Rodríguez, M. Smiglak, Fluid Phase Equilibr (2016) 408:1e9

Developing energy efficient lignin biomass processing - towards understanding mediator behaviour in ionic liquids

M. Eshtaya, A. Ejigu,  G.Stephens,   D.A. Walsh, G.Z. Chen, A.K. Croft,Faraday Discuss. (2016) 190:127-145

Recovery of ibuprofen from pharmaceutical wastes using ionic liquids

F.A. e Silva,  M. Caban,  P. Stepnowski,  J.A.P. Coutinho, S.P.M. Ventura, Green Chem. (2016) 18:3749-3757

A comparative study of electrochemical degradation of imidazolium and pyridinium ionic liquids: A reaction pathway and ecotoxicity evaluation

A. Pieczyńska, A. Ofiarska, A.F. Borzyszkowska, A. Białk-Bielińska, P. Stepnowski, S. Stolte, E. M. Siedlecka, Sep. Purif. Technol. (2015) 156:522–534

Preliminary study on suitability of ionic liquids as potential passive-sampling media of polyaromatic-hydrocarbon (PAH) analyses in water

J. Maszkowska, E. Synak, A. Fabiańska, M. Caban, S. Stolte, P. Husson, M.F. Costa Gomes, R. Synak, P. Stepnowski, Anal. Bioanal. Chem. (2015) 407(12):3531–3536

Protonic Ammonium Nitrate Ionic Liquids and Their Mixtures: Insights into Their Thermophysical Behavior

J.N. Canongia Lopes, J.M. S. S. Esperança, A. Mão de Ferro, A.B. Pereiro, N.V. Plechkova, L.P.N. Rebelo, K.R. Seddon,  I. Vazquez-Fernández, J. Phys. Chem. B (2016) 120(9):2397–2406

Exceptional activity of gallium(III) chloride and chlorogallate(III) ionic liquids for Baeyer-Villiger oxidation

M. Markiton,  A. Chrobok,  K. Matuszek,  K.R. Seddon,  M.Swadźba-Kwaśny,RSC Adv., (2016) 6:30460-30467

Ionic liquids derived from organosuperbases: en route to superionic liquids

Janusz Nowicki, Marcin Muszynski and Jyri-Pekka Mikkola; RSC Adv., 6, 9194, 2016

Properties modification by eutectic formation in mixtures of ionic liquids
O. Stolarska, A. Soto, H. Rodríguez, M. Smiglak; RSC Advances, 5, 22178- 22187, 2015

The effect of n vs. iso isomerization on the thermophysical properties of aromatic and non-aromatic ionic liquids
Ana S.M.C. Rodrigues, Hugo F.D. Almeida, Mara G. Freire, José A. Lopes-da-Silva, João A.P. Coutinho, Luís M.N.B.F. Santos; Fluid Phase Equilibria, 423, 190-202, 2016

Deconstruction of the green alga Ulva rigida: Closing the mass balance
Ricardo Pezoa-Conte, Alyson Leyton, Ikenna Anugwom, Sebastian von Schoultz, Jorma Paranko, Päivi Mäki-Arvela, Stefan Willför, Marcin Muszyński, Janusz Nowicki, María Elena Lienqueo, Jyri-Pekka Mikkola; Algal Research, 12, 262-273, 2015

Second generation bioethanol from Eucalyptus globulus Labill and Nothofagus pumilio: ionic liquid pretreatment boosts the yields
Maria Elena Lienqueo, María Cristina Ravanal, Ricardo Pezoa-Conte, Victoria Cortínez, Loreto Martinez, Tomas Niklitschek, Oriana Salazar, René Carmona, Alejandro García, Sari Hyvärinen, Päivi Mäki-Arvela, Jyri-Pekka Mikkola; Industrial Crops and Products, 80, 148–155, 2016

Plasma membrane permeabilisation by ionic liquids: a matter of charge
Hartmann DO, Shimizu K, Siopa F, Leitão MC, Afonso CAM, Canongia Lopes JN, Silva Pereira C.; Green Chemistry, 17, 4587-4598, 2015

Effect of the Methylation and N–H Acidic Group on the Physicochemical Properties of Imidazolium-Based Ionic Liquids
Ana S. M. C. Rodrigues, Marisa A. A. Rocha, Hugo F. D. Almeida, Catarina M. S. S. Neves, José A. Lopes-da-Silva, Mara G. Freire, João A. P. Coutinho, and Luís M. N. B. F. Santos; J. Phys. Chem. B, 119, 8781–8792, 2015

Ex-situ reconstitution of the plant biopolyester suberin as a film
Garcia H, Ferreira R, Martins C, Sousa AF, Freire CSR, Silvestre AJD, Kunz W, Rebelo LPN, Silva Pereira C.; Biomacromolecules, 15, 1806–1813, 2014

Toxicity of Ionic Liquids: past, present and future
Hartmann DO, Silva Pereira C.; Ionic Liquids in Lipid Processing and Analysis: opportunities and challenges. Edited by Xu X, Guo Z, Cheong L-Z. Urbana: AOCS Press, 2015, Chapter 13, 403-421

Pioneering biological processes in the presence of ionic liquids: the potential of filamentous fungi
Petkovic M, Silva Pereira C.; Ionic Liquids UnCOILed: Critical Expert Overviews. Edited by Plechkova NV, Seddon KR. New Jersey: John Wiley & Sons, Inc, 2012, Chapter 9, 283-303

Properties modification by eutectic formation in mixtures of ionic liquids
O. Stolarska, A. Soto, H. Rodríguez, M. Smiglak; RSC Advances, 5, 22178- 22187, 2015

Triphilic Ionic-Liquid Mixtures: Fluorinated and Nonfluorinated Aprotic Ionic-Liquid Mixtures
Oldamur Hollûczki, Marina Macchiagodena, Henry Weber, Martin Thomas, Martin Brehm, Annegret Stark, Olga Russina, Alessandro Triolo, Barbara Kirchner; ChemPhysChem, 16, 3325-3333, 2015

Ionic liquids based on phosphonium cations as neat lubricants or lubricant additives for a steel/steel contact
I. Otero, E. R. López, M. Reichelt, M. Villanueva, J. Salgado, J. Fernandez; ACS Applied Materials & Interfaces, 6, 13115-13128, 2014

Ionic liquids as unforeseen assets to fight life-threatening mycotic diseases
Hartmann DO, Petkovic M, Silva Pereira C.. Frontiers in Microbiology, 2015, submitted

Enhanced extraction of proteins using cholinium-based ionic liquids as phase-forming components of aqueous biphasic systems
M. V. Quental, M. Caban, M. M. Pereira, P. Stepnowski, J.A.P. Coutinho, M.G. Freire, Biotechnology Journal (2015) 19:1457

In silico prediction of linear free energy relationship descriptors of neutral and ionic compounds
Cho C.-W., Stolte S., Yun Y.-S., Krossing I., Thöming J. (2015) RSC Advances 5, 80634-80642

Mobility and biodegradability of an imidazolium based ionic liquid in soil and soil amended with waste sewage sludge
Markiewicz M., Jungnickel C., Cho C.-W., Stolte S. (2015) Environmental Science: Processes & Impacts 17, 1462–1469

Catalytically active perrhenate based ionic liquids: A preliminary ecotoxicity and biodegradability assessment
Thu H.B.T., Markiewicz M., Thöming J., Reich R.M., Korinth V., Cokoja M., Kühn F.E., Stolte S. (2015)  New Journal of Chemistry 39, 5431--5436

Structural and Ecotoxicological Profile of N-Alkoxymorpholinium-based Ionic Liquids
Salchner R., Laus G., Haslinger S., Kahlenberg V., Wurst K., Braun D.E., Vergeiner S., Kopacka H., Schottenberger H., Puckowski A., Markiewicz M., Stolte S., Nerdinger S. (2014)  HETEROCYCLES 90(2), 1018-1037. Published online, October 3, 2014, DOI: 10.3987/COM-14-S(K)73

Quantitative Analysis of Molecular Interaction Potentials of Ionic Liquid Anions Using Multi-functionalized Stationary Phases in HPLC
Cho C.-W., Stolte S., Ranke J., Preiss U., Krossing I. and Thöming J. (2014)  ChemPhysChem 15, 2351 – 2358

Biodegradability of 27 pyrrolidinium, morpholinium, piperidinium, imidazolium and pyridinium ionic liquid cations under aerobic conditions
Neumann J., Steudte S., Cho, C.-W., Thöming J., and Stolte S. (2014)  Green Chemistry 16, 2174–2184

Toxicity and biodegradability of dicationic ionic liquids
Steudte S., Bemowsky S., Mahrova M., Bottin-Weber U., Tojo-Suarez E., Stepnowski P., and Stolte S. (2014)  RSC Advances 4(10), 5198-5205

Bacterial consortium and axenic cultures isolated from activated sewage sludge for biodegradation of imidazolium based ionic liquid
Markiewicz M., Henke J., Brillowska-Dabrowska A., Stolte S., Luczak J., Jungnickel C. (2014)  International Journal of Environmental Science and Technology 11, 1919–1926

Biodegradation potential of cyano-based ionic liquid anions in a culture of Cupriavidus spp. and their in vitro enzymatic hydrolysis by nitrile hydratase
Neumann J., Pawlik M., Bryniok D., Thöming J., Stolte S. (2014)  Environmental Science and Pollution Research Int. 21 (16), 9495–9505


Short term missions:

Magda Caban

Partition of mandelic acid by applying ABS based in chiral ionic liquids

Nicole Vieira

Ecotoxicity of fluorinated ionic liquids

Lukasz Halinski

Method development for the isolation and determination of ionic liquid-triggered free sphingoid bases in fungi

Alan Puckowski

Toxicity and biodegradation study of dicationic ionic liquids

Matheus Pereira

Synthesis of glycine-betaine- based-ionic liquids for the development of novel strategies regarding the purification of added-value proteins

Vanessa Correia

Elucidating the native structure of cutin macromolecules depolymerised by an ionic liquid

Wenzhong Zhang

Functionalized ionic liquid intercalated into layered inorganic titanium phosphate materials for separation of scandium

Fatima Moscoso

Towards the use of Ionic Liquids as Bioavailability Promoters for Aromatic Pollutants

Magda Caban

Protocol for stability study of pharmaceuticals in ionic liquid matrices

Diego Hartmann

Exploring ionic liquids effects on fungi: elucidating the role of sphingolipid signalling


Patented industrial applications:

The BASSIL process
BASF SE, “Method for the Separation of Acids from Chemical Reaction Mixtures by Means of Ionic Fluids,” World Patent WO/2003/062251, Jul. 31, 2003.
BASF SE, “Method for Isolating Acids from Chemical Reaction Mixtures by Using 1-Alkylimidazoles,” World Patent WO2005/061416, Jul. 7, 2005.
Breaking azeotropes processes
A.B. Pereiro, J.M.M. Araújo, J.M.S.S. Esperança, I.M. Marrucho, L.P.N. Rebelo,  Ionic liquids in separations of azeotropic systems – A review. The Journal of Chemical Thermodynamics Volume 46, March 2012, Pages 2–28
Cellulose dissolution process
Dissolution and processing of cellulose using ionic liquids 
US patent US 20030157351 A1
Aluminium plating process
Electric Al or Al alloy plating bath using room temperature molten salt bath and plating method using the same. Patent number: 8821707
Dipsol Chemicals Co., Ltd., Honda Motor Co., Ltd.
Companies using ILs on industrial scale:
  • BASF
  • Eastman Chemical Company
  • IFP (Institut Franc¸ais du Pe´trole) – Axens
  • DEgussa
  • Central Glass Co., Ltd., Japan
  • IoLiTec
  • ExxonMobil
  • Chevron and Chevron Phillips
  • BP
  • PetroChina
  • Linde 
Useful links:
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Data publikacji: środa, Grudzień 2, 2015 - 11:04; osoba wprowadzająca: Alan Puckowski Ostatnia zmiana: czwartek, Czerwiec 8, 2017 - 09:50; osoba wprowadzająca: Alan Puckowski